Big problem.

Interview: Bob Mankoff, New Yorker cartoon editor
by Mark Hurst
April 08, 2005

"It’s a 3-year research project with their psychology department, using New Yorker cartoons to see how people process humor."

Read the entire interview.

In case you don't see the problem. The New Yorker Cartoon Bank

Compare.

Funny:
The Therapist
America We Stand As One - [h/t Garfield Ridge]
Get Fuzzy

Used to be funny:
The Onion

Not all that funnny:
Rip Taylor
The Family Circus

Not funny at all:
The New Yorker Cartoon Bank